Osteo-K Minis®

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Bone Support

Formulated by physicians from Harvard, Cornell, MIT, and Bastyr

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Osteo-K Minis®
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SAFETY: From a large number of clinical trials using dosages in excess of 40 mg/day, there were no reports of side effects associated with any type of hypercoagulable (increased blood clotting) state. Both animal and clinical studies support the conclusion that MK4 has no dangerous effects on blood clotting. More than 6,000 people with AML, MDS, osteoporosis, Parkinson disease, Alzheimer disease, hepatocellular carcinoma, liver failure, liver cirrhosis, myelofibrosis and kidney failure on hemodialysis have taken 45 mg daily (and higher doses) of MK4 for up to eight years without any serious side effects. However, it should be noted that the anticoagulant effect of warfarin, functioning by its interference with the clotting effect of vitamin K, can be offset with as little as 1 mg of vitamin K. If you are on anticoagulant therapy (e.g., taking warfarin), you should not take Osteo-K or Osteo-K Minis. For everyone else, Osteo-K and Osteo-K Minis are safe.

Calcium and vitamin D decrease how fast people lose bone minerals; however, MK4 in the amounts found in Osteo-K and Osteo-K Minis have been shown to actually increase bone mineral density and decrease fracture risk.

Don't be fooled by other bone health formulas that contain vitamin K. Only Osteo-K contains the amount and form used in clinical trials—45 milligrams (nearly all other formulas contain much smaller amounts, measured in micrograms, which can be hundreds of times less than what's in Osteo-K). And other products contain MK7, another form of vitamin K, but which has never been shown in clinical trials to reduce fractures. Only MK4 reduces fractures. MK4 (45 mg daily) is so effective that it's been an approved by the Ministry of Health in Japan since 1995 for the treatment of osteoporosis.

MK4 (45 mg/d) alone and in combination with vitamin D3 and calcium matches or exceeds the benefits in clinical trials of Fosamax, Actonel and Boniva without the dangerous side effects.

MK4 exerts a powerful influence on promoting bone health and is one of the most frequently prescribed nutrients in Japan for growing strong bones and decreasing fractures. MK4 is a fat soluble vitamin that is a coenzyme for a vitamin K-dependent carboxylase enzyme catalyzing the carboxylation of the amino acid, glutamic acid, resulting in its conversion to gamma-carboxyglutamic acid (Gla).

Although vitamin K-dependent gamma-carboxylation occurs only on specific glutamic acid residues in a small number of proteins, it is critical to the calcium-binding function of those proteins. Three vitamin-K dependent proteins have been isolated in bone. Osteocalcin is a protein synthesized by osteoblasts (bone forming cells). The synthesis of osteocalcin by osteoblasts is regulated by the active form of vitamin D, 1,25(OH)2D3 or calcitriol. The mineral-binding capacity of osteocalcin requires vitamin K-dependent gamma-carboxylation of three glutamic acid residues.

Matrix Gla protein (MGP) has been found in bone, cartilage, and soft tissue, including blood vessels. The results of animal studies suggest MGP prevents the calcification of soft tissue and cartilage, while facilitating normal bone growth and development.

Vitamin D3, the active form of vitamin D, is involved in many physiological processes. It increases calcium absorption, and has been shown in clinical trials alone and in combination with MK4 and calcium, to reduce fracture risk in osteoporosis.

Calcium is essential for bones and teeth, heart, nerves, muscles, and blood clotting. About 99% of the calcium in the body is found in bones and teeth, while the other 1% is found in the blood and soft tissue. Calcium supplementation has been shown in clinical trials to increase bone mineral density. Providing supplemental calcium is the standard of care for people with low bone mineral density.

Take two capsules twice daily with food.

CAUTION: Do not take this product if you are taking anticoagulant medication (e.g. warfarin). Vitamin K interferes with warfarin.


Supplement Facts

Serving Size: 2 Capsules
Servings Per Container: 60

Amount Per Serving % Daily Value
Vitamin D3 (as cholecalciferol) 1000 IU 250%
Vitamin K2 (as K2, Menaquinone-4, MK4™) 22500 mcg 28,125%
Calcium (as citrate) 200 mg 20%

OTHER INGREDIENTS:Vegetable cellulose capsules, rice flour, and l-leucine.

This product contains NO yeast, wheat, gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservative, or flavoring. Hypoallergenic.

MK4™ is a registered trademark of Nutritional Biochemistry, Inc. (NBI). All rights reserved.

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Although we try to keep product information up-to-date and error-free, sometimes formulation changes may occur without notice. Please read all product labels carefully to confirm ingredients, warnings, and dosage before using any supplements. If you ever receive a product which differs from what is represented, please let us know and we'll be happy to make it right.

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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